Experiment no 9 : By observing effect of acetylcholine on heart rate and force of contraction on isolated heart of a frog | P&C

 Experiment no 9 : By observing effect of acetylcholine on heart rate and force of contraction on isolated heart of a frog.

experiment no 9

  Questions

1 Write the mechanism of action of acetylcholine .

2  Why there is decrease in heart rate and force of contraction?

3 List five drugs having parasympathomimetic action

4 Which type of effect is produced by Acetylcholine?

5. Name and write the location of muscarinic receptors in the body

6 Name and write the location of nicotinic receptors in the body.

7 Draw the graph (dose response) of effect of acetylcholine on the heart

8List five drugs having parasympathomimetic action.

9. List five drugs having parasympatholytic action.

10. What is your interpretation from the graph?

 

(answers)

 

Q . 1Ans- Mechanism of Action of Acetylcholine –

i)Acetylcholine produce Negative chatronopic & Negative Inotopic effect on heart .

ii)Acetylcholine mainly act on Muscarinic a nicotinic receptor .

 

Q . 3 Ans-  Drugs having parasympathomimetic action –

 Acetylcholine. Methacoline, Bethanochol Carbacaol, pilocarpine etc..

 

Q . 4 Ans - Negative chronotopic & Negative inotropic effect is produced by Acetylcholine .

 

Q.5 Ans - Name & locations of Muscarinic receptors –

M1 – CNS , gqnglia, gastric parietal cells .

M2 - Av Node of atria

M3 -  Exocrine gland & smooth muscles,

 

Q .6 Ans - Name location of Nicotinic receptor

NM – (Nicotinic Muscle) - skeletal Neuromuscular Junction.

NN - Nicotinic  Neuro → CNS & Autonomic Ganglia,