Experiment no 8 : The Effect of calcium ion and potassium ions on heart rate and force contraction on isolated heart of a frog by using the CD of MSBTE.

2nd year pharmacology and toxicology experiment d pharma
experiment no 8


Questions

1 How a Calcium ion produces contraction of heart?

2. Why there is increase in heart rate and force of contraction?

3. Which type of effect is produced by Calcium ions?

4 Which type of effect is produced by Potassium ione?

5 What will be the effect if the dose of Calcium ions is increased?

6 What will be the effect, if the dose of Potassium ions is increased?

7 How the concentration of calcium within the cells is increased?

8. Draw the graph of effect of calcium ions on isolated heart of a trog

9 Draw the graph of effect of Potassium ions on isolated heart of a frog  .

10. What is your interpretation from the graph?

 

(answers)

 

Q. 1 Ans - The calcium that enters the heart cell through the calcium ion channrl activated the ryodine receptors to release enough calcium from the sacroplasmic reticulum to initiate heart muscle anti _Hon this is done by binding to another Structure med troponin, inside the heart muscle

 

Q .3. Ans calcium ions have two effect on the phosphatidycholine membrane is softening effect at dower concentration and hardening at higher Concentration.

Q .4. Ans The most dangerous effect of Hyperkalemia is on the cardiac muscle. If the potassium concentration is rapidly, there is including greater risk of cardiac armythmics. ng ventricular Fibrillation & arystote.

 

0.5 Ans changes is the frequency of stimulation do not effect the speed with which calcium Jack depress the ventricular response. it concluded that calcium lock depress the contr ontrastivity of Heart.

 

0.6. Ans potassium ions produce a repolarization of the vascular smooth muscle of the coronaries, leading to vasorelaxation redistance the Nat let - ATP are pump & an increase of the membrane conductance of potassium .